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Which statement by a client receiving methimazole indicates a therapeutic response?

  1. "I have been sleeping less since I started the medication."

  2. "I have gained 3 pounds since my last appointment."

  3. "My bowel movements have become more frequent."

  4. "I urinate more often than before."

The correct answer is: "I have gained 3 pounds since my last appointment."

In the context of hyperthyroid treatment, methimazole is an antithyroid medication used to decrease the amount of thyroid hormone produced by the thyroid gland. A therapeutic response to methimazole typically involves the alleviation of symptoms associated with hyperthyroidism, which includes weight stability or weight gain in some cases. For individuals with hyperthyroidism, weight loss is common due to increased metabolism. Therefore, an increase in weight, such as a client reporting a weight gain of 3 pounds since starting the medication, suggests that the medication is effectively controlling the hyperthyroid condition. This weight gain indicates a shift towards a more stable metabolic state, reflecting improved thyroid function and symptom management. In contrast, sleep disturbances, increased bowel movements, and more frequent urination—mentioned in the other statements—are indicative of ongoing hyperthyroid symptoms. Therefore, the weight gain response signifies a therapeutic effect of the methimazole, confirming its effectiveness in managing the client's condition.